The Role of Macrophages During Mammalian Tissue Remodeling and Regeneration Under Infectious and Non-Infectious Conditions

Several infectious pathologies in humans, such as tuberculosis or SARS-CoV-2, are responsible for tissue lung damage, requiring regeneration. The regenerative capacity of adult mammals is limited to few organs. Critical injuries non-regenerative organs trigger a repair process that leads definitive architectural and functional disruption, while superficial wounds result scar formation. Tissue lesions mammals, commonly studied under non-infectious conditions, cell death at the site injury, well production danger signals favouring massive recruitment immune cells, particularly macrophages. Macrophages also paramount importance infected injuries, characterized by presence pathogenic microorganisms, where they must respond both infection damage. In this review, we compare processes implicated non-infected versus two organs, skeletal muscles lungs, focusing on primary role We discuss negative impact macrophage responses possible routes investigation new therapies improve recovery state seen with COVID-19 patients.